VOTUBIA

Reason for request

Clinical Benefit

Substantial

Substantial AB

Clinical Added Value

moderate

Given the efficacy of VOTUBIA (everolimus) in reducing renal angiomyolipoma volume associated with tuberous sclerosis complex in adult patients, VOTUBIA provides a substantial improvement in actual benefit (IAB III) in the treatment of patients not requiring immediate surgery (nephrectomy or embolisation).