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MEKINIST (trametinib), protein kinase inhibitor

ONCOLOGY - New indication
Opinions on drugs - Posted on Mar 18 2016

Reason for request


Moderate improvement as first-line treatment of unresectable or metastatic melanoma, in patients with a BRAF V600 mutation

  • MEKINIST now has Marketing Authorisation in combination with dabrafenib, in the treatment of adults with unresectable or metastatic melanoma with a BRAF V600 mutation.
  • Combining MEKINIST with dabrafenib improves progression-free survival and overall survival in comparison with dabrafenib alone.

Clinical Benefit



Clinical Added Value



Therapeutic use




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