TALTZ (ixekizumab), immunosuppressive interleukin IL-17A inhibitor

DERMATOLOGY - New medicinal product
Opinions on drugs - Posted on Jan 26 2017

Reason for request


No clinical advantage demonstrated relative to COSENTYX.

  • TALTZ has Marketing Authorisation in the treatment of moderate to severe plaque psoriasis in adults who require systemic therapy.
  • Its superiority to ENBREL (etanercept) and to STELARA (ustekinumab) has been demonstrated, but it has not been compared to COSENTYX (sekukinumab), another IL-17A inhibitor.
  • TALTZ should be reserved for the treatment of plaque psoriasis in adults, in patients with severe chronic plaque psoriasis, defined by a failure (insufficient response, contraindication or intolerance) in at least two treatments including nonbiologic systemic treatments and phototherapy AND an extensive form and/or substantial psychosocial impact.



Clinical Benefit




Clinical Added Value

no clinical added value


Therapeutic use


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