INCRELEX (mecasermin), somatropin
ENDOCRINOLOGY - Update
Opinions on drugs - Posted on Oct 04 2017
Reason for request
Renewal of inclusion
Minor clinical added value in the management of growth delays related to a severe primary IGF-1 deficiency
- INCRELEX (recombinant human IGF-1) has had marketing authorisation since 2007 in the long-term treatment of growth delays in children and adolescents aged 2 to 18 years with a severe primary IGF-1 deficiency.
- Its effect on growth is variable and is difficult to assess, given the low amount of data available and the wide variability of effect from one patient to another.
- It is the only treatment available for the management of severe primary IGF-1 deficiency, so the benefit must be assessed with regard to the frequency of its short-term adverse effects, in particular hypoglycaemia.
Clinical Added Value
Évaluation des médicaments