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FAMPYRA (fampridine), voltage-dependent potassium channel blocker

NEUROLOGY - Update
Opinions on drugs - Posted on Feb 20 2019

Reason for request

Renewal of inclusion

Low clinical benefit in the management of walking disorders in multiple sclerosis patients

 

  • FAMPYRA has been granted a marketing authorisation for the improvement in walking ability of patients suffering from multiple sclerosis (MS) and presenting with a walking handicap (EDSS 4-7).

  • The data derived from a new phase III study have confirmed its modest efficacy versus placebo on walking ability, along with the existence of a small fraction of responders that cannot be identified beforehand.

  • Its tolerance profile is marked by high, though relatively infrequent risks of convulsions, severe hypersensitivity and urinary tract infection.

  • It failed to improve the quality of life of the patients in the clinical studies.

 


Clinical Benefit

Low

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